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Opinion|Videos|April 9, 2026

Driving Guideline-Aligned Care in EGFR-Mutated NSCLC

Author(s)Alexander Spira, MD, PhD, FACP, FASCO, Ticiana Leal, MD, Natalie Vokes, MD

Fact checked by: Justin Mancini

In this segment, Dr. Alexander Spira and Dr. Ticiana Leal discuss variability in treatment selection for early-stage EGFR-mutated non–small cell lung cancer (NSCLC) and strategies to promote guideline-aligned care. Dr. Leal highlights that despite clear recommendations, differences in practice patterns persist, particularly in community settings.

Episodes in this series

EP. 1 Evolving Adjuvant Therapy in Early-Stage EGFR-Mutated NSCLC: Insights From ADAURA

EP. 1 Evolving Adjuvant Therapy in Early-Stage EGFR-Mutated NSCLC: Insights From ADAURA

EP. 2 Neoadjuvant Strategies and Early Biomarker Testing in EGFR-Mutated NSCLC

EP. 2 Neoadjuvant Strategies and Early Biomarker Testing in EGFR-Mutated NSCLC

EP. 3 EGFR Biology and Treatment Selection Beyond PD-L1 in EGFR-Mutated NSCLC

EP. 3 EGFR Biology and Treatment Selection Beyond PD-L1 in EGFR-Mutated NSCLC

EP. 4 Osimertinib Across Stages: Shaping Early-Stage EGFR-Mutated NSCLC Care

EP. 4 Osimertinib Across Stages: Shaping Early-Stage EGFR-Mutated NSCLC Care

EP. 5 Interpreting EGFR-TKI Evidence for Early-Stage EGFR-Mutated NSCLC

EP. 5 Interpreting EGFR-TKI Evidence for Early-Stage EGFR-Mutated NSCLC

EP. 6 Real-World Outcomes With EGFR-TKIs in Early-Stage EGFR-Mutated NSCLC

EP. 6 Real-World Outcomes With EGFR-TKIs in Early-Stage EGFR-Mutated NSCLC

EP. 7 Biomarker Testing at Diagnosis in Early-Stage EGFR-Mutated NSCLC

EP. 7 Biomarker Testing at Diagnosis in Early-Stage EGFR-Mutated NSCLC

EP. 8 Multidisciplinary Coordination in EGFR-Mutated NSCLC Treatment Planning

EP. 8 Multidisciplinary Coordination in EGFR-Mutated NSCLC Treatment Planning

EP. 9 Neoadjuvant Decision-Making in EGFR-Mutated NSCLC

EP. 9 Neoadjuvant Decision-Making in EGFR-Mutated NSCLC

EP. 10 Setting Expectations for Long-Term Therapy in EGFR-Mutated NSCLC

EP. 10 Setting Expectations for Long-Term Therapy in EGFR-Mutated NSCLC

EP. 11 Managing EGFR-TKI Toxicities in Early-Stage EGFR-Mutated NSCLC

EP. 11 Managing EGFR-TKI Toxicities in Early-Stage EGFR-Mutated NSCLC

EP. 12 Driving Guideline-Aligned Care in EGFR-Mutated NSCLC

EP. 12 Driving Guideline-Aligned Care in EGFR-Mutated NSCLC

EP. 13 Shared Decision-Making in Early-Stage EGFR-Mutated NSCLC

EP. 13 Shared Decision-Making in Early-Stage EGFR-Mutated NSCLC

EP. 14 Patient Selection for Adjuvant Therapy in EGFR-Mutated NSCLC

EP. 14 Patient Selection for Adjuvant Therapy in EGFR-Mutated NSCLC

EP. 15 Motivating Treatment Persistence in EGFR-Mutated NSCLC

EP. 15 Motivating Treatment Persistence in EGFR-Mutated NSCLC

EP. 16 Long-Term Toxicity Management in EGFR-Mutated NSCLC

EP. 16 Long-Term Toxicity Management in EGFR-Mutated NSCLC

EP. 17 Counseling Persistence in EGFR-Mutated NSCLC Therapy

EP. 17 Counseling Persistence in EGFR-Mutated NSCLC Therapy

EP. 18 Biopsy-Driven Neoadjuvant Planning in EGFR-Mutated NSCLC

EP. 18 Biopsy-Driven Neoadjuvant Planning in EGFR-Mutated NSCLC

EP. 19 Defining Meaningful Outcomes in Neoadjuvant EGFR-Mutated NSCLC

EP. 19 Defining Meaningful Outcomes in Neoadjuvant EGFR-Mutated NSCLC

EP. 20 Surgical Considerations After Neoadjuvant Therapy in EGFR-Mutated NSCLC

EP. 20 Surgical Considerations After Neoadjuvant Therapy in EGFR-Mutated NSCLC

EP. 21 Transitioning to Adjuvant Therapy in EGFR-Mutated NSCLC

EP. 21 Transitioning to Adjuvant Therapy in EGFR-Mutated NSCLC

EP. 22 The Role of Early Biomarker Testing in EGFR-Mutated NSCLC

EP. 22 The Role of Early Biomarker Testing in EGFR-Mutated NSCLC

In this segment, Dr. Alexander Spira and Dr. Ticiana Leal discuss variability in treatment selection for early-stage EGFR-mutated non–small cell lung cancer (NSCLC) and strategies to promote guideline-aligned care. Dr. Leal highlights that despite clear recommendations, differences in practice patterns persist, particularly in community settings. The discussion emphasizes the importance of increasing awareness of current guidelines, reinforcing the role of molecular testing, and ensuring that treatment decisions are driven by tumor biology. Dr. Leal also notes the value of education, peer-to-peer engagement, and multidisciplinary collaboration in aligning clinical practice with evidence-based standards. The panel addresses how reducing reliance on non–guideline-aligned approaches can help optimize patient outcomes. This segment underscores the need for consistent application of evidence-based strategies to ensure that patients with EGFR-mutated NSCLC receive the most appropriate care in the curative-intent setting.

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