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Opinion|Videos|March 25, 2026

Neoadjuvant Strategies and Early Biomarker Testing in EGFR-Mutated NSCLC

Author(s)Alexander Spira, MD, PhD, FACP, FASCO, Ticiana Leal, MD, Natalie Vokes, MD

NEADORA data highlights why early NGS guides resectable EGFR lung cancer care, favoring perioperative osimertinib and avoiding checkpoint inhibitors.

Episodes in this series

EP. 1 Evolving Adjuvant Therapy in Early-Stage EGFR-Mutated NSCLC: Insights From ADAURA

EP. 1 Evolving Adjuvant Therapy in Early-Stage EGFR-Mutated NSCLC: Insights From ADAURA

EP. 2 Neoadjuvant Strategies and Early Biomarker Testing in EGFR-Mutated NSCLC

EP. 2 Neoadjuvant Strategies and Early Biomarker Testing in EGFR-Mutated NSCLC

In this segment, Dr. Alexander Spira and Dr. Ticiana Leal explore how emerging neoadjuvant strategies are influencing the management of early-stage EGFR-mutated non–small cell lung cancer (NSCLC). The discussion focuses on the growing relevance of trials such as NeoADAURA and how they are reshaping treatment planning in resectable disease. Dr. Leal highlights the increasing importance of obtaining comprehensive biomarker testing at the time of initial diagnostic biopsy, rather than waiting for surgical specimens, to ensure that targeted treatment options can be considered earlier in the disease course. The panel discusses how earlier identification of EGFR mutations enables more informed multidisciplinary decision-making, particularly when evaluating the role of neoadjuvant therapy. This evolving approach reflects a shift toward integrating molecular insights upfront to optimize sequencing strategies and improve outcomes in patients with EGFR-mutated NSCLC in the curative-intent setting.

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