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Opinion|Videos|March 25, 2026

Evolving Adjuvant Therapy in Early-Stage EGFR-Mutated NSCLC: Insights From ADAURA

Author(s)Alexander Spira, MD, PhD, FACP, FASCO, Ticiana Leal, MD, Natalie Vokes, MD

Experts explain how adjuvant osimertinib changes post-surgery EGFR lung cancer care, from rapid testing to real-world adherence.

Episodes in this series

EP. 1 Evolving Adjuvant Therapy in Early-Stage EGFR-Mutated NSCLC: Insights From ADAURA

EP. 1 Evolving Adjuvant Therapy in Early-Stage EGFR-Mutated NSCLC: Insights From ADAURA

EP. 2 Neoadjuvant Strategies and Early Biomarker Testing in EGFR-Mutated NSCLC

EP. 2 Neoadjuvant Strategies and Early Biomarker Testing in EGFR-Mutated NSCLC

In this opening segment, Dr. Alexander Spira sets the stage for a discussion on the evolving treatment landscape of early-stage EGFR-mutated non–small cell lung cancer (NSCLC). Dr. Edward Kim reflects on the pivotal findings from the ADAURA trial and how they have reshaped clinical practice in the adjuvant setting. The conversation highlights the significance of disease-free survival and overall survival outcomes observed with adjuvant osimertinib in patients with resected stage IB to IIIA EGFR-mutated NSCLC. Dr. Kim also discusses how longer-term follow-up data have strengthened clinician confidence in incorporating EGFR-targeted therapy as part of curative-intent treatment. The panel emphasizes the shift toward routine molecular testing and personalized treatment strategies, underscoring how these data have influenced decision-making and standard of care in early-stage EGFR-mutated NSCLC.

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