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Opinion|Videos|April 9, 2026

Biomarker Testing at Diagnosis in Early-Stage EGFR-Mutated NSCLC

Author(s)Alexander Spira, MD, PhD, FACP, FASCO, Ticiana Leal, MD, Natalie Vokes, MD

Fact checked by: Justin Mancini

In this segment, Dr. Alexander Spira and Dr. Edward Kim discuss the critical role of early and comprehensive biomarker testing in the management of early-stage EGFR-mutated non–small cell lung cancer (NSCLC).

Episodes in this series

EP. 1 Evolving Adjuvant Therapy in Early-Stage EGFR-Mutated NSCLC: Insights From ADAURA

EP. 1 Evolving Adjuvant Therapy in Early-Stage EGFR-Mutated NSCLC: Insights From ADAURA

EP. 2 Neoadjuvant Strategies and Early Biomarker Testing in EGFR-Mutated NSCLC

EP. 2 Neoadjuvant Strategies and Early Biomarker Testing in EGFR-Mutated NSCLC

EP. 3 EGFR Biology and Treatment Selection Beyond PD-L1 in EGFR-Mutated NSCLC

EP. 3 EGFR Biology and Treatment Selection Beyond PD-L1 in EGFR-Mutated NSCLC

EP. 4 Osimertinib Across Stages: Shaping Early-Stage EGFR-Mutated NSCLC Care

EP. 4 Osimertinib Across Stages: Shaping Early-Stage EGFR-Mutated NSCLC Care

EP. 5 Interpreting EGFR-TKI Evidence for Early-Stage EGFR-Mutated NSCLC

EP. 5 Interpreting EGFR-TKI Evidence for Early-Stage EGFR-Mutated NSCLC

EP. 6 Real-World Outcomes With EGFR-TKIs in Early-Stage EGFR-Mutated NSCLC

EP. 6 Real-World Outcomes With EGFR-TKIs in Early-Stage EGFR-Mutated NSCLC

EP. 7 Biomarker Testing at Diagnosis in Early-Stage EGFR-Mutated NSCLC

EP. 7 Biomarker Testing at Diagnosis in Early-Stage EGFR-Mutated NSCLC

EP. 8 Multidisciplinary Coordination in EGFR-Mutated NSCLC Treatment Planning

EP. 8 Multidisciplinary Coordination in EGFR-Mutated NSCLC Treatment Planning

EP. 9 Neoadjuvant Decision-Making in EGFR-Mutated NSCLC

EP. 9 Neoadjuvant Decision-Making in EGFR-Mutated NSCLC

EP. 10 Setting Expectations for Long-Term Therapy in EGFR-Mutated NSCLC

EP. 10 Setting Expectations for Long-Term Therapy in EGFR-Mutated NSCLC

In this segment, Dr. Alexander Spira and Dr. Edward Kim discuss the critical role of early and comprehensive biomarker testing in the management of early-stage EGFR-mutated non–small cell lung cancer (NSCLC). Dr. Kim emphasizes the importance of obtaining molecular testing results at the time of initial diagnostic biopsy rather than waiting for surgical specimens, particularly as neoadjuvant treatment strategies continue to evolve. The discussion highlights how early identification of actionable mutations, such as EGFR alterations, enables more informed treatment planning and supports timely multidisciplinary decision-making. Dr. Kim also notes that delays in biomarker testing can limit access to appropriate targeted therapies and impact sequencing decisions in the curative-intent setting. This segment reinforces the shift toward integrating molecular testing earlier in the care pathway to optimize treatment selection and improve outcomes for patients with EGFR-mutated NSCLC.

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