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Opinion|Videos|April 1, 2026

Osimertinib Across Stages: Shaping Early-Stage EGFR-Mutated NSCLC Care

Author(s)Alexander Spira, MD, PhD, FACP, FASCO, Ticiana Leal, MD, Natalie Vokes, MD

In this segment, Dr. Alexander Spira and Dr. Edward Kim discuss how the clinical development of osimertinib across multiple disease stages has influenced treatment expectations in early-stage EGFR-mutated non–small cell lung cancer (NSCLC).

Episodes in this series

EP. 1 Evolving Adjuvant Therapy in Early-Stage EGFR-Mutated NSCLC: Insights From ADAURA

EP. 1 Evolving Adjuvant Therapy in Early-Stage EGFR-Mutated NSCLC: Insights From ADAURA

EP. 2 Neoadjuvant Strategies and Early Biomarker Testing in EGFR-Mutated NSCLC

EP. 2 Neoadjuvant Strategies and Early Biomarker Testing in EGFR-Mutated NSCLC

EP. 3 EGFR Biology and Treatment Selection Beyond PD-L1 in EGFR-Mutated NSCLC

EP. 3 EGFR Biology and Treatment Selection Beyond PD-L1 in EGFR-Mutated NSCLC

EP. 4 Osimertinib Across Stages: Shaping Early-Stage EGFR-Mutated NSCLC Care

EP. 4 Osimertinib Across Stages: Shaping Early-Stage EGFR-Mutated NSCLC Care

In this segment, Dr. Alexander Spira and Dr. Edward Kim discuss how the clinical development of osimertinib across multiple disease stages has influenced treatment expectations in early-stage EGFR-mutated non–small cell lung cancer (NSCLC). Dr. Kim reflects on the evolution of osimertinib from the metastatic setting to its role in the adjuvant setting, highlighting how consistent efficacy and central nervous system activity have contributed to its broader adoption. The conversation explores how data generated across disease settings have helped establish confidence in targeted therapy as a key component of curative-intent treatment strategies. Dr. Kim also notes that the strength of evidence supporting osimertinib has helped shape clinician expectations regarding durability of benefit and long-term outcomes. This segment underscores how a strong and consistent clinical evidence base can inform treatment paradigms and drive earlier integration of targeted therapies in EGFR-mutated NSCLC.

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