May 6th 2024
Investigators analyzed data from the Center for International Blood and Marrow Transplant Research who underwent autologous or allogeneic transplants.
Patient, Provider, and Caregiver Connection: Addressing Pediatric and AYA Patient Concerns While Managing Hodgkin Lymphoma
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Patient, Provider, and Caregiver Connection™: Individualizing Care for Patients with Schizophrenia—Understanding Patient Challenges and the Role of Innovative Treatment
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Improving Outcomes in Autoimmune Hemolytic Anemias at the Intersection Between Hematology and Oncology Care
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B-Cell Tumor Board: Rendering Real World Personalized Treatment Plans in CLL/SLL and MCL Through the Lens of Emerging BTKi Evidence
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Applying New Evidence in Multiple Myeloma Care from Frontline to R/R Disease
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Community Practice Connections™: 5th Annual Precision Medicine Symposium – An Illustrated Tumor Board
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Community Oncology Connections™: Overcoming Barriers to Testing, Trial Access, and Equitable Care in Cancer
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Translating New Evidence into Treatment Algorithms from Frontline to R/R Multiple Myeloma: How the Experts Think & Treat
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Medical Crossfire: How Has Iron Supplementation Altered Treatment Planning for Patients with Cancer-Related Anemia?
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Medical Crossfire®: The Experts Bridge Recent Data in Chronic Lymphocytic Leukemia With Real-World Sequencing Questions
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Community Practice Connections™: Pre-Conference Workshop on Immune Cell-Based Therapy
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Imatinib Discontinuation in Chronic Phase CML Doesn’t Always Lead to Relapse
June 15th 2013Almost half of patients with chronic-phase chronic myeloid leukemia (CML) who discontinued imatinib treatment did not relapse, according to results of a prospective study. Those who did relapse showed continued sensitivity to imatinib when treatment started again.
ASCO: Pomalidomide New Standard of Care in Heavily Pretreated, Relapsed Multiple Myeloma
June 3rd 2013Pomalidomide in combination with low-dose dexamethasone had a highly significant benefit on progression-free survival and overall survival compared with single-agent high-dose dexamethasone in patients with relapsed or refractory multiple myeloma, according to updated results of the MM-03 trial presented at the ASCO 2013 Annual Meeting.
ASCO: Prolonged Survival in Multiple Myeloma Predicted Using Deep Sequencing
June 3rd 2013Multiparameter flow cytometry and deep sequencing were both able to accurately identify patients with multiple myeloma who were negative for minimal residual disease, a factor that was found to better predict prolonged survival compared with complete response as measured by traditional response criteria.
Radiotherapy Is NOT Essential to Cure Diffuse Large B-Cell Non-Hodgkin Lymphoma
May 15th 2013DLBCL of any stage remains a systemic disease with early hematogenous spread. Thus, arguments advocating the role of IFRT do not truly address disease biology, and all future efforts to cure patients will require improved systemic therapy.
Novel Agents Now Prevalent Method of Care for Multiple Myeloma
May 2nd 2013A majority of patients with multiple myeloma are being treated with novel agents such as thalidomide, bortezomib, and lenalidomide within a year of diagnosis instead of the chemotherapeutic regimens that were more prevalent a decade ago, according to a new study.
Osteopontin Identified as Potential New Target in Treatment of ALL
April 24th 2013Targeting the bone marrow–specific extracellular matrix osteopontin may be an effective strategy to increase the efficacy of chemotherapy in patients with acute lymphocytic leukemia, according to the authors of a recent study.
EPOCH-Rituximab Therapy Obviates Need for Radiotherapy in B-Cell Lymphoma
April 23rd 2013A dose-adjusted regimen of etoposide, doxorubicin, and cyclophosphamide with vincristine, prednisone, and rituximab (DA-EPOCH-R) obviated the need for radiotherapy in patients with primary mediastinal B-cell lymphoma in a single-group, phase II, prospective study.
Long-Term Treatment With Imatinib Affected Bone Mineral Density
April 16th 2013A majority of patients on imatinib for treatment of GIST or CML had low or absent levels of osteocalcin, a bone marker secreted by osteoblasts, and about 50% of patients had a decrease in bone mineral density, signaling that long-term treatment may affect bone health in these patients.
Nilotinib for CML Leads to Fewer Treatment-Emergent Mutations Than Imatinib
April 12th 2013CML patients treated with nilotinib had fewer treatment-emergent BCR-ABL mutations than those treated with imatinib, and among patients who did have a mutation, those treated with nilotinib had reduced rates of progression to accelerated phase and blast phase of the disease.
Novel Antibody Directed at Chronic Lymphocytic Leukemia
April 4th 2013Researchers have identified a novel monoclonal antibody directly targeted against a receptor found in abundance on chronic lymphocytic leukemia (CLL) cells, but not normal B cells. The humanized antibody can directly kill CLL cells.
New Monoclonal Antibody Targets Intracellular Oncogenic Proteins in Leukemias
March 27th 2013Researchers have discovered a fully human “T-cell receptor–like” monoclonal antibody specific for the Wilms tumor 1 oncoprotein-an intracellular oncogenic transcription factor that is overexpressed in a wide range of leukemias, as well as solid cancers.
Translocations Less Common in African American Men With Multiple Myeloma
March 23rd 2013African American men with multiple myeloma had a significantly lower frequency of IgH translocations, a signal of nonhyperdiploid multiple myeloma, compared with European American men, according to the results of a new study published in Blood.
Methotrexate/Asparaginase Combo for Pediatric AML May Be Effective Salvage Therapy
March 19th 2013Combination chemotherapy with sequential administration of methotrexate and asparaginase was found to be effective salvage therapy in a small retrospective study of pediatric patients with relapsed or refractory acute myeloid leukemia (AML).
CML Stem Cell Burden at Diagnosis Associated With Treatment Outcomes
March 11th 2013Contrary to previous laboratory findings, a new study has shown for the first time the effect of stem cell burden on treatment outcome, discovering that tyrosine kinase inhibitors, including imatinib and dasatinib, can rapidly eradicate most chronic myeloid leukemia stem cells.
Targeting GFI1 May Improve Prognosis in ALL, Study Suggests
February 26th 2013Findings of a newly published study by an international team of researchers suggest that targeting growth factor independence 1 (GFI1) may improve the prognosis of patients with T-cell acute lymphoblastic leukemia or other lymphoid leukemias.
Targeting Leukemic Stem Cells in Marrow Could Stave Off TKI Resistance
February 20th 2013New research suggests that a novel, investigative drug could help alleviate some of the resistance to tyrosine kinase inhibitor treatment seen in chronic myeloid leukemia (CML). The drug, a pan-BCL2 inhibitor called sabutoclax, could sensitize malignant leukemic stem cells in the bone marrow niche to TKI treatment.