Oncology Vol 28 No 4

Radium-223 vs EBRT for Multiple Painful Bone Metastases: Is Less More?

April 15, 2014

There is no question that radiopharmaceuticals have a role in the management of patients with metastatic bone disease. There is also no question that fractionated external beam radiotherapy (EBRT) is highly effective and generally well tolerated when delivered with large open or focal fields.

Radium-223 vs EBRT for Multiple Painful Bone Metastases: The Data Favor Radium-223

April 15, 2014

In order to achieve maximum survival of patients with metastatic castration-resistant prostate cancer, the judicious use of all available effective agents and modalities is required. Both EBRT and radium-223 are effective at relieving pain, but both may decrease bone marrow function.

HER2-Positive Breast Cancer: The Story Goes On

April 15, 2014

It will be critically important to await the longer-term DFS and OS results from the neoadjuvant studies, as well as the adjuvant studies evaluating dual HER2 blockade, prior to these approaches truly becoming the standard of care.

Diffuse Large B-Cell Lymphoma: One Treatment No Longer Fits All

April 15, 2014

Rationally designed clinical trials investigating novel agents in patient populations enriched for those who are most likely to benefit will be instrumental for expediting progress. With respect to DLBCL, it has become clear that one treatment no longer fits all.

Diffuse Large B-Cell Lymphoma: Changing Treatment Paradigms

April 15, 2014

With the progress in diagnostic methods that has made it possible to decipher the genetic code of DLBCL within a relatively short time, and with the increasing number of drugs that are entering clinical trials, our next big challenge is to enroll patients in trials in a timely manner.

HER2 Targeting in Early Breast Cancer: More Options and More Questions

April 15, 2014

Therapies targeting HER2 have revolutionized the treatment of breast cancer. Trastuzumab is the foundation of treatment for women with HER2-positive breast cancer. The challenge ahead is to develop predictors that can identify patients for whom trastuzumab alone will be sufficient.

Appropriate Management of Molecular Subtypes of Diffuse Large B-Cell Lymphoma

April 15, 2014

The classification of diffuse large B-cell lymphoma into three distinct molecular diseases--germinal center B-cell–like subtype, an activated B-cell–like subtype, and a primary mediastinal B-cell lymphoma subtype--has laid the foundation for the development of new agents and novel strategies that target individual subtypes.

Palliative Radiotherapy for Prostate Cancer

April 15, 2014

This review will include discussion of the role of radiation therapy for osseous metastases and metastatic spinal cord compression, as well as the use of radiopharmaceuticals for painful osseous metastases.

The Daily Miracle of Palliative Radiotherapy for Prostate Cancer

April 15, 2014

It is important for all of us now and then to take a step back and recapture the wonder that we all felt at the onset of our careers, when treatments we now consider simple and routine held an aura of miracle. For me, a little bit of that wonder returns every time I treat a patient with a bony metastasis-in particular, from prostate cancer.