Disparities in Treatment/Survival Outcomes Observed in Metastatic PDAC
Higher social vulnerability index was independently associated with lower odds of meeting at least one quality criterion in treatment for PDAC.
100 Non-Pharmacological Interventions for Managing Abemaciclib-Associated Adverse Events in Patients With Early/Advanced HR+/HER2– Breast Cancer: A US-Based Health Care Provider Survey
Adding Chemo to Radiotherapy Did Not Improve Survival Outcomes in Cervical Cancer
The addition of chemotherapy to radiotherapy did not show significant improvements in OS when compared with radiotherapy alone in patients with intermediate-risk cervical cancer.
Highlighting Challenges to Patient Treatment in Rare Lymphomas
A paucity of prospective, well-vetted data to guide therapy in patients with rare lymphomas may result in a reliance on expert consensus guidelines.
Pancreatic/Colorectal Adenocarcinoma Rates Have Increased in Young Adults
Although the overall incidence of colorectal adenocarcinoma is decreasing, the reduction is primarily associated with patients 55 years or older.
Pembrolizumab/Docetaxel Does Not Improve OS/rPFS Outcomes in mCRPC
Results from the KEYNOTE-921 trial demonstrated that pembrolizumab with docetaxel did not elicit efficacy improvements vs placebo with docetaxel in prostate cancer.
Artificial Intelligence in Cancer Care: Addressing Challenges and Health Equity
Artificial intelligence may mitigate overdiagnosis and unnecessary treatments in cancer care by integrating with precision medicine.
Genetic Data May Inform Personalized Radiotherapy Strategies for Cancer Care
Testing a patient’s genetics may influence decisions such as using longer courses of radiotherapy, says Rachit Kumar, MD.
102 Novel Prognostic and Predictive Locoregional Biosignature for Risk Stratification of Early-Stage Hormone Receptor–Positive Breast Cancer
Miami Breast Cancer Conference Provided Exciting Updates and Engaging Discussions
Neil M. Iyengar, MD, discussed the most prevalent discussions and exciting updates from the 2025 Miami Breast Cancer Conference.
Robot-Assisted Esophagectomy Achieves “Best Outcome Data” in Study
Robot-assisted minimally invasive esophagectomies with anastomotic technique were completed without complications or mortality in a majority of patients.
Tarlatamab Displays Overall Survival Benefit in Relapsed SCLC
The safety profile for tarlatamab was consistent with its known profile in patients with relapsed small cell lung cancer.
Elucidating Lorlatinib Benefit, ALK TKI Sequencing in ALK-Positive NSCLC
Phase 3 CROWN trial findings suggest that patients with ALK-positive NSCLC may maintain efficacy even after reducing lorlatinib dosing to mitigate AEs.
103 Leveraging Digital Technology to Improve Breast Cancer Patients’ Understanding of Treatment Recommendations
Collaborating to Improve Prostate Cancer Survival, Health Care Utilization
Multidisciplinary collaboration may help in minimizing the treatment burden among patients with prostate cancer, according to Curtiland Deville Jr, MD.
Isa-VRd Shows Efficacy and Safety in Frail Transplant-Ineligible Myeloma
Subgroup data from the IMROZ trial showed Isa-VRd improved survival and responses vs VRd alone in patients who were frail with newly diagnosed myeloma.
Multidisciplinary AE Education Enables Safer Inpatient/Outpatient BiTE Therapy
Multidisciplinary education on toxicities such as CRS and ICANS improves the safety and management of bispecific T-cell engager therapies in outpatient settings.
104 Identification of Ductal Carcinoma In Situ Patients With Low-Risk Clinicopathology Who Benefit From Radiation Therapy With and Without Endocrine Therapy After Breast-Conserving Surgery Assessed With the 7-Gene Biosignature
Plasma-Based MRD Analysis May Predict Recurrence in EGFR-Mutant NSCLC
A disease-free survival and minimal residual disease event-free status was maintained for most patients with adjuvant osimertinib for EGFR-mutant NSCLC.
Molecular Diagnostics, PIPAC Appear "Exciting" in GI Cancer Surgical Care
Spatial transcriptomics and multiplex immunohistochemistry from samples may elucidate outcomes for patients who undergo surgical care for cancer.
Mitigating NALIRIFOX-Related Diarrhea May Extend Survival in Metastatic PDAC
Post hoc analysis of the NAPOLI 3 trial suggests that proactively managing NALIRIFOX-induced diarrhea could allow patients with PDAC to remain on treatment longer.
Social Determinants of Health Affect Acupuncture Expectancy in Breast Cancer
Race, education, and arm pain were found to influence acupuncture expectancy in patients who are survivors of breast cancer.
TPS 105 ALISertib in Combination With Endocrine Therapy in Patients With Hormone Receptor-Positive, HER2-Negative Recurrent or Metastatic Breast Cancer: the Phase 2 ALISCA-Breast1 Study
Chemo Effects May Outweigh Obesity-Related GI Alterations in Breast Cancer
Identifying biologic mechanisms driving symptoms may be necessary to develop therapies that reduce symptom burden for patients with breast cancer.
Blinatumomab-Related ICANS Symptoms More Prevalent Than Prior Reports
An objective assessment tool like the ICE Score may standardize grading of neurotoxicity associated with newer bispecific antibodies in hematologic cancer.
FDA Grants IDE to Electrosurgical Device For Breast-Conservation Surgery
The developer will conduct a US feasibility test to evaluate the safety and efficacy of the SIRA RFA Electrosurgical Device in patients who require breast-conservation surgery.
FDA OKs Nivolumab/Ipilimumab in Unresectable/Metastatic HCC
Results from the phase 3 CheckMate 9DW trial of nivolumab/ipilimumab vs lenvatinib or sorafenib led to the approval for patients with unresectable or metastatic HCC.
Post AHSCT Palliative Care Survey Shows Patient Needs, Clinician Perceptions Differ
The Integrated Palliative Care Outcome Scale showed the potential to guide palliative care integration to better help patients and clinicians after AHSCT.
Prospective Study May Clarify PTEG Benefits in Malignant Bowel Obstruction
Future work may focus on optimizing symptom management associated with percutaneous transesophageal gastrostomy placement in malignant bowel obstructions.
Exploring Future Avenues of Growth for Psychosocial Cancer Care
“Psycho-oncology has made remarkable progress; however, there are still critical areas for further development,” Cristiane D. Bergerot, PhD, BS, MS, said.