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Opinion|Videos|January 24, 2025

Clinical Perspectives: Selecting Between Daratumumab- and Isatuximab-Containing Quadruplet Induction Regimens

Author(s)Cristina Gasparetto, MD, Amandeep Godara, MBBS, Ken Shain, MD, PhD

Panelists discuss how the choice between isatuximab-based quadruplet and daratumumab-based regimens in multiple myeloma treatment depends on clinical trial data comparing Isa-KRd vs KRd, with particular emphasis on efficacy outcomes and patient-specific factors that might influence treatment selection.

Episodes in this series

4 experts are featured in this series.

EP. 1 Expert Insights: Evolving Treatment Landscape in NDMM

4 experts are featured in this series.

EP. 2 Key Highlights From the PERSEUS and CASSIOPEIA Studies

4 experts are featured in this series.

EP. 3 ASH 2024 Updates —AURIGA: Daratumumab Plus Lenalidomide in Maintenance Post Transplant

4 experts are featured in this series.

EP. 4 Anti-CD38 Quadruplet Induction Regimens in TE NDMM: New Standard of Care

4 experts are featured in this series.

EP. 5 Clinical Perspectives: Selecting Between Daratumumab- and Isatuximab-Containing Quadruplet Induction Regimens

4 experts are featured in this series.

EP. 6 ASH 2024 Highlights: GMMG-HD7 Study

4 experts are featured in this series.

EP. 7 Where Are We Going? Future Perspectives on Navigating the Treatment Paradigm in Transplant-Eligible NDMM

4 experts are featured in this series.

EP. 8 Key Highlights: CEPHEUS Trial SubQ Dara-VRd vs VRd in Transplant-Eligible or Transplant-Deferred NDMM

4 experts are featured in this series.

EP. 9 Transplant-Ineligible NDMM: When to Use a Quadruplet Regimen

4 experts are featured in this series.

EP. 10 Expert Perspectives: Navigating Between CEPHEUS and IMROZ Studies

4 experts are featured in this series.

EP. 11 Challenges in Treating Frail Patients With NDMM: In the Real-World Practice: Potential Steroid-Free Regimens

4 experts are featured in this series.

EP. 12 Future Perspectives: What’s Next in NDMM?

Treatment with daratumumab-based combination therapies may drive minimal residual disease conversion rates in patients with newly diagnosed multiple myeloma.

EP. 13 Assessing CD38 Monoclonal Antibody-Based Regimens in NDMM

Video content above is prompted by the following:

In what clinical scenario would you consider an isatuximab-based quadruplet over a daratumumab-based regimen?
1. How have the latest data informed your treatment decision?
2. IsKia, Isa-KRd vs KRd

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