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Opinion|Videos|February 7, 2025

Transplant-Ineligible NDMM: When to Use a Quadruplet Regimen

Author(s)Cristina Gasparetto, MD, Amandeep Godara, MBBS, Ken Shain, MD, PhD

Panelists discuss how treatment strategies and sequencing decisions for patients with multiple myeloma who decline transplantation despite eligibility must be carefully tailored, considering both immediate therapeutic goals and potential future treatment options.

Episodes in this series

4 experts are featured in this series.

EP. 1 Expert Insights: Evolving Treatment Landscape in NDMM

4 experts are featured in this series.

EP. 2 Key Highlights From the PERSEUS and CASSIOPEIA Studies

4 experts are featured in this series.

EP. 3 ASH 2024 Updates —AURIGA: Daratumumab Plus Lenalidomide in Maintenance Post Transplant

4 experts are featured in this series.

EP. 4 Anti-CD38 Quadruplet Induction Regimens in TE NDMM: New Standard of Care

4 experts are featured in this series.

EP. 5 Clinical Perspectives: Selecting Between Daratumumab- and Isatuximab-Containing Quadruplet Induction Regimens

4 experts are featured in this series.

EP. 6 ASH 2024 Highlights: GMMG-HD7 Study

4 experts are featured in this series.

EP. 7 Where Are We Going? Future Perspectives on Navigating the Treatment Paradigm in Transplant-Eligible NDMM

4 experts are featured in this series.

EP. 8 Key Highlights: CEPHEUS Trial SubQ Dara-VRd vs VRd in Transplant-Eligible or Transplant-Deferred NDMM

4 experts are featured in this series.

EP. 9 Transplant-Ineligible NDMM: When to Use a Quadruplet Regimen

4 experts are featured in this series.

EP. 10 Expert Perspectives: Navigating Between CEPHEUS and IMROZ Studies

4 experts are featured in this series.

EP. 11 Challenges in Treating Frail Patients With NDMM: In the Real-World Practice: Potential Steroid-Free Regimens

4 experts are featured in this series.

EP. 12 Future Perspectives: What’s Next in NDMM?

Treatment with daratumumab-based combination therapies may drive minimal residual disease conversion rates in patients with newly diagnosed multiple myeloma.

EP. 13 Assessing CD38 Monoclonal Antibody-Based Regimens in NDMM

Video content above is prompted by the following:

For patients who may be eligible for transplantation but decline, what is your preferred treatment approach in this population?
1. How might a patient’s transplant status impact your sequencing strategy?

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