
Opinion|Videos|January 31, 2025
Key Highlights: CEPHEUS Trial SubQ Dara-VRd vs VRd in Transplant-Eligible or Transplant-Deferred NDMM
Panelists discuss how the CEPHEUS study comparing subcutaneous daratumumab plus VRd vs VRd alone in patients with transplant-ineligible newly diagnosed multiple myeloma (NDMM) provides important insights into the role of quadruplet therapy in this specific population.
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Video content above is prompted by the following:
- Let’s transition to patients with NDMM who are considered transplant ineligible or transplant deferred.
- Can you summarize the recent data from the CEPHEUS study evaluating subcutaneous daratumumab plus VRd vs VRd in transplant-ineligible NDMM?
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Updated NCCN Guidelines for multiple myeloma add a dedicated MRD testing framework and expand recommended MRD assessment timepoints.

Experts discussed whether CAR T cells or bispecific antibodies should be used first in relapsed/refractory multiple myeloma at the 2026 SOHO Annual Meeting.
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