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Experts discuss the “transformational” potential of enfortumab vedotin plus pembrolizumab for patients with muscle-invasive bladder cancer.

Sarah Weiss, MD, discussed key IGNYTE trial findings of RP1 and nivolumab in patients with advanced melanoma who progressed on prior anti-PD-1 therapy.

Heath Skinner, MD, PhD, discussed current standards for radiotherapy in head and neck cancers and highlighted multidisciplinary collaboration within UPMC.

Zenocutuzumab has been added to the NCCN’s Clinical Practice Guidelines in Oncology for biliary tract cancers based on results from the phase 2 eNRGy trial.

Among patients with recurrent cervical cancer who received prior immunotherapy, sac-TMT plus pembrolizumab achieved an ORR of 54%.

Combining tisotumab vedotin with carboplatin, pembrolizumab, and optional bevacizumab produces robust responses in first-line recurrent or metastatic cervical cancer.

Roisin E. O’Cearbhaill, MD, discussed the MUC16 × CD28 bispecific antibody REGN5668 in treating patients with recurrent ovarian or endometrial cancer.

Although ctDNA has limited utility in well-differentiated disease, it may have use in monitoring molecular residual disease in high-grade carcinomas.

The primary and secondary end points of the TANGENT trial were met when patients with tenosynovial giant cell tumor were treated with emactuzumab.

Although not yet mature, overall survival data trended in favor of pirtobrutinib plus venetoclax/rituximab in the phase 3 BRUIN CLL-322 trial.

The FDA has granted FTD and cleared an IND application for daretabart, an anti-GD2 monoclonal antibody, for the treatment of high-risk neuroblastoma.

Involving transplant physicians early on is critical in myelofibrosis therapy, said Nicolaus Kröger, MD.

Phase 1 data show that anti-BCMA CAR-T cells can be generated directly within a patient without a need for leukapheresis and lymphodepleting chemotherapy.

Results from the phase 3 RASolute 302 trial showed that daraxonrasib improved median OS compared with standard chemotherapy in metastatic PDAC.

Elizabeth Mittendorf, MD, PhD, discusses Clarity Breast, an FDA-authorized AI tool that predicts 5-year breast cancer risk using standard 2D mammograms.

At the MRD assessment on day 45, patients with large B-cell lymphoma treated with cema-cel saw a median decrease of 97.7% in their plasma ctDNA levels.

Among all patients with gynecologic malignancies who received a formal radiation cystitis diagnosis, 87.5% received treatment and 56.0% were referred to a urologic specialist.

PFS showed statistically significant improvement with darovasertib plus crizotinib in the first line for patients with HLA-A*A2:01–negative metastatic uveal melanoma.

Young patients with breast cancer should always aim to advocate for themselves, said Shari Goldfarb, MD.

Across both pretreated cervical cancer and PROC populations, no new safety signals and low rates of treatment discontinuation were observed with DB-1311/BNT324.

Making pancreatic cancer an immunotherapy-receptive disease requires identifying select patient subgroups who may benefit.

Combining ctDNA and modern imaging with novel therapeutics may help determine subsets of patients who are eligible to receive reduced treatment courses.

Orca-T may facilitate faster immune reconstitution in patients who undergo allogeneic transplant, according to Wendy Stock, MD.

Ting Bao, MD, MS, suggested chemotherapy-induced neuropathy could be mitigated through acupuncture, although phase 3 clinical trial results are pending.

A prospective evaluation shows that using large language models within an oncology-specific knowledge graph may help close oncology's enrollment crisis.

An analysis conducted by Starr and associates showed that patients with high disease burden in the liver did not experience liver failure with PRRT.

In the phase 3 NRG-GY019 trial, while letrozole monotherapy was more tolerable, it did not achieve noninferiority compared with chemotherapy and letrozole.

Activity stemming from abemaciclib plus letrozole was most pronounced in chemotherapy-naive patients with advanced endometrioid endometrial carcinoma.

Updated results from the phase 2 RAMP 201 trial show that avutometinib plus defactinib provides durable efficacy and a manageable safety profile in patients with LGSOC.

The SISTER trial was the first national randomized trial to demonstrate significantly improved outcomes for black women with endometrial cancer.

Microsatellite instability-high status may make patients suitable candidates to receive agents like pembrolizumab, according to Steven Bialick, DO.