Breast Cancer

In 21 patients with metaplastic breast cancer receiving neoadjuvant chemotherapy, 48% achieved pCR—higher than prior estimates—with all pCR patients alive and disease-free at follow-up, suggesting modern regimens including pembrolizumab may improve outcomes in this chemoresistant subtype.

In 391 Venezuelan breast cancer patients receiving NACT, normal BMI was associated with higher pCR (31.6% vs 15.8% overweight and 14.7% obese) and significantly better OS at 120 months, supporting BMI as a relevant prognostic and predictive factor.

In this institutional retrospective review, 14.4% of clinically node-negative patients meeting SOUND trial criteria had nodal metastases on SLNB, underscoring the need for careful multidisciplinary decision-making before integrating axillary staging de-escalation into practice.

A retrospective review found progressive adoption of Choosing Wisely guidelines for sentinel lymph node biopsy omission in elderly patients with early-stage breast cancer, with younger age and earlier year of diagnosis as the strongest predictors of biopsy performance.

Four experts discussed how new breast cancer ADC trial results guide treatment sequencing, as well as practical tips for managing Dato-DXd dry eye and other adverse effects.

In 58 patients undergoing excisional biopsy for discordant imaging and pathology, 16% had malignant pathology on excision; palpable lesions were the only factor independently associated with upstage to malignancy (adjusted OR 7.50).

Implementing in-office genetic testing at a diverse MedStar Georgetown breast oncology practice increased genetic counseling completion from 31.3% to 45.2% and lowered mean age at testing from 55.6 to 48.4 years, with gains across all racial groups.

In 167 patients with HR+/HER2− breast cancer after neoadjuvant chemotherapy, lymphovascular invasion, number of positive sentinel nodes, and >50% positive sentinel nodes were the strongest predictors of high axillary burden; a nomogram was developed to guide axillary management decisions.

This literature review of 10 studies found that anemia is common during NAC, with restrictive transfusion thresholds and intravenous iron supplementation showing favorable safety profiles, while ESA use and blood transfusions raised concerns about oncologic outcomes.

A decision tree cost-utility analysis found ICG more cost-effective than methylene blue for SLNB in breast cancer (ICER $4,044/QALY), with Monte Carlo simulation showing an 80% probability of ICG superiority.

Compared with wire-guided needle localization, MOLLI localization was associated with shorter median OR delays, fewer overall delays, and an estimated combined annual opportunity cost benefit of nearly $673,000.

Early adoption of the MOLLI wireless localization system demonstrated a rapid learning curve, fewer missed biopsy clips, and a significant reduction in operating room delays compared with traditional needle localization.

In 161 biopsied breast masses, malignant lesions showed significantly higher E-strain ratios than benign lesions (3.51 vs 1.93), with progressive increases across BI-RADS categories, supporting elastography as an adjunct to biopsy decision-making.

Learn how ctDNA liquid biopsies sharpen prognosis, detect residual disease, and guide breast cancer care, plus where evidence says to wait.

This literature review and institutional case report describes primary NECB with synchronous pancreatic and liver metastases as an extraordinarily rare, aggressive phenotype requiring multidisciplinary management driven by tumor biology rather than surgery.

Post-surgical pyoderma gangrenosum was successfully managed following bilateral mastectomy after clinical recognition prompted a shift to immunosuppressive therapy, avoiding further surgical debridement and achieving eventual wound healing.

The MagUS magnetically-guided ultrasound biopsy technique enabled successful sentinel lymph node biopsy de-escalation in 7 patients who preferred axillary evaluation to surgical staging, with all pathology returning negative.

In 42 patients with DCIS undergoing breast-conserving surgery, 71.4% had detectable disseminated cancer cells in bone marrow, with residual-risk DCISionRT score significantly correlated with higher DCC burden compared with low- and elevated-risk groups.

This survey-based TIP study examines patient-perceived barriers to home recovery after mastectomy within a single ERAS-enabled hospital system, aiming to identify why patients decline same-day discharge despite being clinically eligible.

In 433 patients undergoing breast surgery, median VAS pain scores declined from 2 on day 1 to 0 by day 30, with severe pain in only 7.4% and opioid use in 2.5%, supporting nonopioid-based analgesic protocols.

In 1153 women undergoing breast imaging and NCB, BIRADS 5 status, symptomatic presentation, and age over 70 years were associated with shorter time to biopsy, while socioeconomic and demographic factors were not significant predictors of delay.

In a retrospective multi-institution study of 267 early-stage breast cancer patients, the TumorSight Viz AI algorithm achieved landmark identification and measurement accuracy comparable to inter-radiologist variability, generating results in an average of 8 minutes per patient.

The first reported case of xanthogranulomatous mastitis in a pregnant patient was managed conservatively, avoiding surgery during pregnancy; a literature review of 24 cases found co-incidence of malignancy in 14% of excised lesions.

Routine intraoperative frozen section analysis of sentinel lymph nodes after neoadjuvant chemotherapy did not improve surgical outcomes and led to unnecessary axillary lymph node dissection in over half of intraoperatively positive cases.

In this prospective multicenter study, the next-generation MarginProbe device (MP2) achieved sensitivity of 76.8% and specificity of 49.1% for intraoperative lumpectomy margin assessment, meeting all predefined success criteria and earning FDA approval in September 2025.