Videos

The COPERNICUS study, an ongoing phase two trial, evaluated amivantamab-based regimens in EGFR-mutant non-small cell lung cancer across two cohorts, first-line and post-osimertinib progression, with a key focus on implementing mandatory prophylactic skin and DVT regimens, resulting in dramatically lower rash rates (4% grade 3+) compared to the original MARIPOSA trial.

Panelists discuss the pivotal MARIPOSA trial, which examined combining amivantamab with lazertinib versus osimertinib monotherapy, showing improvements in progression-free survival (23.7 vs. 16.6 months), overall survival, CNS efficacy, and particularly strong benefits in high-risk subgroups such as TP53-mutant patients. Safety data from the trial highlighted the importance of prophylactic measures, especially for rash and other adverse events, noting that with current prophylaxis protocols, serious toxicity rates have been significantly reduced compared to the original study.

Dr. Nunnery describes TROPION-Breast02 studying Dato-DXd in frontline patients with metastatic TNBC for patients ineligible for immunotherapy, similar to ASCENT-03 design but with important differences in eligibility criteria.

Expert panel explains extremely high-risk cutaneous SCC after surgery and radiation, and why adjuvant cemiplimab may curb recurrence.

Dr. Ajai Chari and NP Samantha Shenoy examine the long-term efficacy outcomes from the MAIA trial and discuss the clinical significance of response depth in newly diagnosed multiple myeloma (NDMM). The faculty review progression-free survival improvements, increasing rates of complete response, and the achievement of minimal residual disease (MRD) negativity with daratumumab-based therapy compared with the control regimen. The conversation focuses on how responses may continue to deepen with ongoing treatment and explores the relationship between MRD negativity, durable disease control, and long-term patient outcomes. Dr. Chari and NP Shenoy also discuss the evolving role of MRD assessment as a tool for evaluating treatment effectiveness and highlight how long-term follow-up data can inform clinical decision-making regarding continued therapy. The discussion emphasizes practical interpretation of the MAIA findings and their relevance to contemporary frontline management strategies for patients with NDMM.

Learn how clinicians define daratumumab refractoriness vs exposure and why the 60-day rule guides smarter second-line myeloma choices.

Experts unpack advanced cutaneous squamous cell carcinoma risks, comorbidities, and PD-1/PD-L1 immunotherapy strategies for unresectable disease.

Experts unpack unresectable cutaneous squamous cell carcinoma, weighing PD-1/PD-L1 immunotherapy benefits and risks in older, comorbid patients.

Experts unpack earlier use of BCMA bispecific antibodies in relapsed myeloma, guiding second-line choices, sequencing, and real-world safety management.

Dr. Ajai Chari and NP Samantha Shenoy review the design and long-term follow-up results of the MAIA trial and discuss their clinical implications for the management of newly diagnosed multiple myeloma (NDMM) in transplant-ineligible patients. The faculty examine key efficacy outcomes, including progression-free survival, overall survival, and minimal residual disease (MRD) negativity, while highlighting the continued deepening of responses observed with ongoing daratumumab-based therapy. Dr. Chari and NP Shenoy discuss the relevance of continuous treatment until disease progression, the durability of clinical benefit demonstrated with extended follow-up, and the applicability of the MAIA patient population to everyday clinical practice. The conversation also addresses safety and tolerability considerations associated with long-term treatment and explores how these findings have influenced frontline treatment decisions and expectations for sustained disease control in patients with NDMM.

Real-world cemiplimab data and neoadjuvant results show strong responses in high-risk cutaneous SCC, guiding treatment for frail, complex patients.

Dr. Nunnery discusses ASCENT-07, which moved SG earlier in the treatment sequence for HR-positive disease, allowing patients progressing on endocrine therapy to receive the ADC immediately rather than requiring intervening chemotherapy. Surprisingly, this frontline comparison against standard chemotherapy yielded negative results without statistically significant PFS improvement.

Steven K. Libutti, MD, FACS, discussed the amenities that makes the new Melchiorre Cancer Center a warm and welcoming facility for patients.

Guilherme Perini, MD, PhD, explained the rationale behind the KEYFORM-008 trial, exploring how targeting LAG-3 can reverse checkpoint inhibitor resistance.

Reviewing the HIMALAYA Trial of Tremelimumab Plus Durvalumab in Unresectable HCC

Navigating the Treatment Landscape in Advanced Hepatocellular Carcinoma

Nicholas Hornstein, MD, PhD discusses ctDNA in colorectal cancer, the INTERCEPT-TT trial, building Northwell's GI oncology program, and what better drugs will look like.

New trials show BCMA bispecifics and CAR‑T boost survival in early relapsed, high‑risk myeloma, outperforming Dara-based triplets.

Experts unpack how frontline CD38 quadruplets reshape relapse strategy and high‑risk definitions, spotlighting talquetamab’s promise in myeloma.

Matthew Matasar, MD, highlighted key phase 3 studies seeking to elucidate the clinical benefit of chemotherapy-free regimens in follicular lymphoma.

Sherry Shen, MD, shares retrospective data on how GLP-1s influence overall survival and safety outcomes among patients with breast cancer.

Sherry Shen, MD, broke down early data from MSK evaluating the role GLP-1s play in survival and helping to manage long-term outcomes in breast cancer.

Dr. Zeidner explores frontline treatment selection strategies, emphasizing the abundance of oral options available at diagnosis and sequencing possibilities throughout patient treatment courses.

Sherry Shen, MD, explained the compounding factors behind weight gain during breast cancer care and why managing cardiometabolic health is vital for survival.

ASCO insights on T-DXd plus pertuzumab in HER2-positive breast cancer: deep, durable responses and practical ILD/radiation safety considerations.

New phase III data reshapes HER2+ breast cancer care, spotlighting T-DXd from neoadjuvant to first-line metastatic, plus CNS and toxicity insights.

New ADC trial data reshapes metastatic breast cancer care: why OS differs, where T-DXd fits, and SG’s frontline gains in TNBC.

Experts unpack new antibody-drug conjugate trial data, sequencing choices, and toxicity management reshaping metastatic breast cancer care.

Eric Miller, MD, discussed the evolving role of immunotherapy, antibody-drug conjugates, and sequential therapeutic strategies for bladder preservation.

Joshua Richter, MD, joins The Moonlight Shift to discuss "cure" in relation to myeloma treatment, the linvoseltamab pipeline journey, and myths surrounding myeloma care.