April 2nd 2024
Jonathan Zager, MD, spoke about the use of observation vs systemic immunotherapy to treat patients with stage IIIA and IIIB melanoma.
Equalizing Inequities™ in Multiple Myeloma Care: Shining a Light on Current Barriers and Opportunities for Improved Outcomes
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Show Me Your Care Plan™: Nursing Considerations for Applying the Latest Approaches Across Care Settings in Melanoma
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Medical Crossfire®: Where Are We in the World of ADCs? From HER2 to CEACAM5, TROP2, HER3, CDH6, B7H3, c-MET and Beyond!
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Community Oncology Connections™: Overcoming Barriers to Testing, Trial Access, and Equitable Care in Cancer
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Tumor-Infiltrating Lymphocyte Therapy Advances Into Melanoma
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Community Practice Connections™: 5th Annual Precision Medicine Symposium – An Illustrated Tumor Board
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Allovectin-7 Immunotherapy Active in Metastatic Melanoma
March 1st 2002NEW YORK-In patients with metastatic cutaneous melanoma who have already failed or are refractory to standard treatment, Allovectin-7, a targeted gene therapy using a nonviral delivery system, can induce both local and systemic responses in tumors injected weekly, results of a multicenter phase II study suggest.
Apomine Stabilizes Melanoma, Has Potential for Prevention
January 1st 2002NEW YORK-A potential chemopreventive agent against melanoma stopped metastatic spread in some patients in a phase I clinical trial, according to a report presented at the Chemotherapy Foundation Symposium XIX (abstract 69). The agent,
Dendritic Cell Function in Sentinel Nodes
January 1st 2002Intraoperative lymphatic mapping and sentinel lymphadenectomy has become an increasingly popular technique for staging the regional lymph nodes in early-stage melanoma. This operative technique allows for detailed pathologic analysis of the first (or sentinel) lymph node in direct connection with the primary tumor, and provides a unique opportunity for assessing potential immunologic interactions between the primary tumor and regional lymph node basin. We performed lymphatic mapping and sentinel lymphadenectomy on 25 patients with early-stage melanoma and resected an additional nonsentinel node in each case. Sentinel and nonsentinel nodes were evaluated by routine pathologic analysis. A portion of each node was processed for expression of the dendritic markers of activation CD80, CD86, and CD40, and their corresponding T-cell receptors CTLA-4 and CD28. Of 25 patients undergoing lymphatic mapping and sentinel lymphadenectomy, 20 (80%) had matched sentinel and nonsentinel nodes. A total of 26 matched lymph node sets were obtained: three pairs from one patient and two from an additional two patients. Reverse transcription polymerase chain reaction analyses of corresponding sections of the sentinel and nonsentinel nodes demonstrated a marked reduction in semiquantitative expression of CD80 (77%), CD86 (77%), and CD40 (85%), as well as CTLA-4 (88%) and CD28 (85%) in sentinel as compared to nonsentinel nodes. The diminished expression of the dendritic cell markers appeared to be unrelated to the B-cell (CD20) and T-cell (CD2) expression. Lymphatic mapping and sentinel lymphadenectomy allows for detailed pathologic and molecular characterization of sentinel nodes. Our results suggest a quantitative reduction in dendritic cell markers in sentinel as compared to nonsentinel nodes, which may be important in the immunologic interaction between the primary site and regional lymph node basin and may also serve as useful criteria for identifying sentinel nodes. [ONCOLOGY 16(Suppl 1):27-31, 2002]
Metastatic Melanoma Responds to HSPPC-96 Vaccine
December 1st 2001MIAMI BEACH-Heat shock protein peptide complex-96 (HSPPC-96, Oncophage), an individualized cancer vaccine, produced complete responses in two patients with metastatic melanoma and long-term stable disease in several others during an Italian phase I-II trial.
‘Mole Patrol’ Free Screenings Lead to Skin Cancer Diagnoses
November 1st 2001SAN DIEGO--The results of a series of five free annual skin cancer screenings has demonstrated that community education and early detection are valuable tools in addressing cancer prevention, said Rosemary Giuliano, ARNP, MSN. She is national clinical research coordinator in the Cutaneous Oncology Program’s Department of Surgery at the H. Lee Moffitt Cancer Center & Research Institute, University of South Florida, Tampa.
Melanoma Screening Yield Is High for Older, At-Risk Men
August 1st 2001NEW YORK-Among men over age 50 with an additional melanoma risk factor, diagnostic yield of melanoma screening is 1 in 219, data from the American Academy of Dermatology (AAD) National Skin Cancer Screening Program show. That yield is high, suggesting the potential cost-effectiveness of this intervention, according to Barbara A. Gilchrest, MD, professor and chairman of dermatology, Boston University.
Dietary Changes May Help Prevent Skin Cancer, Expert Says
August 1st 2001NEW YORK-A variety of simple dietary interventions could prove effective in inhibiting carcinogenesis and reducing the incidence of skin cancers, said James M. Spencer, MD, associate professor of dermatology, Mount Sinai School of Medicine, New York.
Frequent Application of Sunscreen Essential to Avoid Sunburns
August 1st 2001NEW YORK-Many persons who apply sunscreen before spending time outdoors are nevertheless increasing their risk of skin cancer by not applying sunscreen frequently enough to prevent sunburn, recent studies involving skiers at high altitudes suggest.
Sentinel Lymph Node Staging Increases Survival in Node-Negative Melanoma
July 1st 2001WASHINGTON-Node-negative patients with intermediate-to-thick melanomas who underwent node staging by sentinel lymph node (SLN) biopsy had a significant survival advantage over those staged by elective lymph node dissection (ELND) or clinical examination, said Sophie Dessureault, MD, of the University of South Florida H. Lee Moffitt Cancer Center, Tampa. She spoke on behalf of the AJCC (American Joint Committee on Cancer) Melanoma Staging Committee.
Topical DNA Repair Enzyme May Prevent Skin Cancer
May 1st 2001FREEPORT, NY-In a phase III clinical trial of 30 patients with xeroderma pigmentosum, use of a topically applied DNA repair enzyme (T4N5 liposome lotion) for 1 year reduced the incidence of basal cell carcinoma by 30% and actinic keratoses by 68%, compared with placebo.
Tumor Vaccine Boosts Outcome in Stage IIA Melanoma Patients
May 1st 2001VENICE, Italy-Adjuvant therapy with the investigational vaccine Melacine helps prevent relapses in patients with stage IIA melanoma, investigators from the Southwest Oncology Group (SWOG) 9035 Study Group announced at the Fifth World Conference on Melanoma. Mela-cine, being developed by Corixa (Seattle), consists of a mixture of allogeneic melanoma cell lysates plus an immunologic adjuvant (Detox).
Augmerosen, Antisense Drug, in Phase III Testing in Melanoma
April 1st 2001NEW YORK-An antisense drug that targets a protein that interferes with the actions of chemotherapeutic agents is entering phase III trials, said Raymond P. Warrell, Jr., MD, president and chief executive officer, Genta Inc., Berkeley Heights, New Jersey.
Biotherapy Maintenance in Metastatic Melanoma
April 1st 2001NEW YORK-For some stage IV melanoma patients who achieve only a partial response or stable disease on a regimen of biochemotherapy, a maintenance strategy using interleukin-2 (IL-2) may prolong survival and in some instances produce durable complete responses, California researchers have discovered. Steven J. O’Day, MD, associate director, medical oncology, John Wayne Cancer Institute at St. John’s Health Center, Santa Monica, reported the encouraging results of a pilot study of the biotherapy maintenance strategy at the Chemotherapy Foundation Symposium XVIII.
Study Contributes to Evolution of Sentinel Lymph Node Biopsy for Melanoma
February 1st 2001Sentinel lymph node biopsy has rapidly evolved into the standard of care for node-negative melanoma. It has been used at the Roswell Park Cancer Institute (RPCI) since 1993, and through periodic reviews of results, several modifications have been
ODAC Rejects Histamine as Adjuvant Therapy for Melanoma
January 1st 2001BETHESDA, Md-The FDA’s Oncologic Drugs Advisory Committee (ODAC) declined in a unanimous vote to recommend that the agency approve histamine hydrochloride injections (Maxim Pharmaceuticals) for adjuvant use with interleukin-2 (IL-2) in the treatment of adult patients with advanced melanoma that has metastasized to the liver.
New Approaches in the Treatment of Metastatic Melanoma: Thalidomide and Temozolomide
December 2nd 2000Although melanoma is a relatively chemoresistant malignancy, systemic chemotherapy remains the primary treatment for metastatic melanoma. The observation of vasculogenic mimicry in aggressive melanoma has
New Melanoma Regimens Fail to Improve on Interferon
December 1st 2000HAMBURG, Germany-Attempts to improve on interferon-based regimens for melanoma with alternative immuno-stimulant strategies are proving less successful than originally hoped, according to presentations at the 25th Congress of the European Society of Medical Oncology (ESMO).
HLA Phenotype May Determine Efficacy of New Melanoma Vaccine
December 1st 2000SEATTLE-Melanoma patients with specific human leukocyte antigen (HLA) phenotypes may respond better to an investigational therapeutic vaccine known as Melacine than those without the phenotype, Vernon Sondak, MD, reported for the Southwest Oncology Group (SWOG) at the Society of Biological Therapy annual meeting.
Three-Arm Phase II Study of Temozolomide in Metastatic Melanoma: Preliminary Results
November 1st 2000Temozolomide, an oral alkylating agent, has shown activity against metastatic melanoma. The drug is schedule dependent and is given daily for 5 days. Altering the schedule may enhance its activity by depletion of the protein O6-alkylguanine-DNA
SLN Biopsy May Be Sufficient for Some Melanoma Patients
October 1st 2000NEW ORLEANS-Management of some patients with melanoma of the lower extremity could potentially stop with sentinel lymph node (SLN) biopsy, according to results presented at the 68th Annual Scientific Meeting of the American Society of Plastic and Reconstructive Surgeons. The study suggests that regional micrometastases of melanoma in the lower extremity are likely confined to the sentinel lymph nodes harvested by lymphadenectomy in some patients, said Lee L.Q. Pu, MD, PhD, resident in plastic surgery, University of South Florida, Tampa.
Eye Cancer Network Features Extensive Collection of Clinical Photographs
September 1st 2000In the left image, a collar-button shaped choroidal melanoma is seen at lower right. Note the wrinkles in the macular retina caused by tumor growth. At right, after palladium-103 plaque radiation therapy, the choroidal melanoma appears darker and smaller as evidenced by resolution of the macular retinal folds. These photographs of this rare ocular cancer are from the extensive collection of NYU ophthalmologist Paul T. Finger, MD. More ocular images can be seen on the Eye Cancer
Camera Catches Melanoma at Early Stage
August 1st 2000The SIAscope uses light and sophisticated computer software to construct an image of each part of the skin. The technique shows when a mole is invading deeper into the skin than normal, allowing early diagnosis of malignant melanoma. The SIAscope, based on spectrophotometric intracutaneous analysis (SIA), was researched at Birmingham University and developed by Cambridge-based Astron Clinica. It is in clinical trials at various sites in the United Kingdom. Dr. Marc Moncrieff (pictured, left) is one of the doctors conducting the trials.
Mapping Predicts Nodal Status in Colorectal Cancer Patients
June 1st 2000NEW ORLEANS-A prospective study in colorectal cancer patients has found that sentinel lymph node (SLN) mapping correctly predicts the presence or absence of nodal metastases, with a very low incidence of skip metastases (disease in a non-SLN), as it does in melanoma and breast cancer.
Long-Term Follow-Up Data on M-Vax Cancer Vaccine
March 1st 2000Avax Technologies, Inc., has released 9-year follow-up data of stage III melanoma patients from company-sponsored phase II studies of M-Vax, an individualized cell-based vaccine for cancer. Ernest W. Yankee, PhD, the company’s executive vice-president, presented the data at the 26th annual meeting of the Clinical Oncological Society of Australia in Melbourne.